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Inventi Impact: Biomedical Analysis

Articles

  • Inventi:pba/14518/14
    Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating\nTablets in Dogs
    01-Jan-1970 Research 2014 : October - December
    Silvina G Castro, Alicia Dib, Gonzalo Suarez, Daniel Allemandi, Carlos Lanusse, Sergio Sanchez Bruni, Santiago D Palma

    The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to\nimprove the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid\ndisintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole\nbioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was\ngiven in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.

    How to Cite this Article
    CC Compliant Citation: Silvina G. Castro, Alicia Dib, Gonzalo\nSuarez, et al., â??Comparative Plasma Exposure of Albendazole\nafter Administration of Rapidly Disintegrating Tablets in\nDogs,â? BioMed Research International, vol. 2013, Article ID\n920305, 7 pages, 2013. doi:10.1155/2013/920305. Copyright © 2013 Silvina G. Castro et al. This article is distributed under the Creative Commons Attribution License, ( http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly\ncited.
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